Overview

We are seeking a theoretical physicist/applied mathematician/computational biologist to join our multidisciplinary team studying how the immune system controls infection. Cryptococcal meningitis (CM) is fungal infection of immunocompromised responsible for >100, 000 deaths globally each year and 20% of AIDS related deaths. In this project, we are studying a new way that macrophage immune cells can ingest and kill Cryptococcus. We have discovered that macrophages have sub-micron ridges on their surface which enhances their ability to interact and phagocytose Cryptococcus.

Using your expertise in analytical and computation methods you will perform research to understand the biophysics of host pathogen interactions in human infections. You will be able to contribute significantly to the ongoing research of the Johnston lab, by designing, developing, and performing research along with appropriate data analysis approaches, so the ability to work independently is essential. You will become a member of a passionate scientific research team that aims to understand fundamental aspects of biology relating to human disease. Your career development will be well supported and your development as an independent research scientist will be encouraged.

Main duties and responsibilities

• Use analytical and computation methods to understand the biophysics of host pathogen interactions in human infections.
• Work as part of a multidisciplinary team across human infection, in vivo and cell models, analytical and computational theoretical models.
• Carry out research and development necessary to the aims of the project.
• Take a lead role in data analysis and preparation for publication.
• Contribute to the writing of research reports, progress reports and presentations.
• Disseminate research findings locally through seminars, and (inter)nationally through publications and conference presentation.
• Develop scientific background and specialist knowledge by reading academic papers and attending conferences and meetings.
• Maintain an accurate and complete record of research and findings.
• Maintain a safe working environment, including ensuring compliance with legislation and undertaking of risk assessments.
• Provide help to other researchers in the same group and other groups with related research interests.
• As a member of staff you will be encouraged to make ethical decisions in your role, embedding the University sustainability strategy into your working activities wherever possible.
• Carry out other duties, commensurate with the grade and remit of the post

Person Specification

Our diverse community of staff and students recognises the unique abilities, backgrounds, and beliefs of all. We foster a culture where everyone feels they belong and is respected. Even if your past experience doesn't match perfectly with this role's criteria, your contribution is valuable, and we encourage you to apply. Please ensure that you reference the application criteria in the application statement when you apply.

Essential criteria

A PhD (or equivalent experience) in a relevant area e.g. theoretical physics/applied mathematics/computational biology

Experience of both analytical and computational methods

Ability to plan and conduct complex experimental analyses, and critically appraise experimental data objectively through statistical analysis

Ability to manage time and prioritise workload effectively with the ability to develop creating solutions to problems

Ability to work as part of a team with varied skills, disciplinary background and experience and to maintain effective communication with team members and collaborators

Attention to detail and a proven ability to keep accurate and reliable records

Ability to present results orally and prepare papers for publication at a high standard

All essential criteria will be assessed at application and interview stages.

Desirable criteria

Experience of collaboration with biologists and/or clinical sciences

Experience of biophysics research

Both desirable criteria will be assessed at application and interview stages.

Further Information

Grade: 7

Salary: £37,999 - £40,247

Work arrangement: Full-time

Duration: Start no later 1/6/24 and end by 31/5/2028

Line manager: Professor of Infection Biology

Direct reports: None

Our website: https://www.sheffield.ac.uk/smph

For informal enquiries about this job contact
Dr Simon Johnston, Professor of Infection Biology: on s.a.johnston@sheffield.ac.uk

Next steps in the recruitment process

It is anticipated that the selection process will take place on week commencing 17 March 2025. This will consist of an interview and presentation. We plan to let candidates know if they have progressed to the selection stage on the week commencing 10 March 2025. If you need any support, equipment or adjustments to enable you to participate in any element of the recruitment process you can contact the Staffing Team at clinmed-staffing@sheffield.ac.uk.

Our vision and strategic plan

We are the University of Sheffield. This is our vision: sheffield.ac.uk/vision (opens in new window).
 

What we offer

• A minimum of 41 days annual leave including bank holiday and closure days (pro rata) with the ability to purchase more.
• Flexible working opportunities, including hybrid working for some roles.
• Generous pension scheme.
• A wide range of discounts and rewards on shopping, eating out and travel.
• A variety of staff networks, providing opportunities for social interaction, peer support and personal development (for example, Race Equality, LGBT+, Women’s and Parent’s networks).
• Recognition Awards to reward staff who go above and beyond in their role.
• A commitment to your development access to learning and mentoring schemes; integrated with our Academic Career Pathways.
• A range of generous family-friendly policies
  • paid time off for parenting and caring emergencies
  • support for those going through the menopause
  • paid time off and support for fertility treatment
  • and more

More details can be found on our benefits page: sheffield.ac.uk/jobs/benefits (opens in a new window).

We are a Disability Confident Employer. If you have a disability and meet the essential criteria for this job you will be invited to take part in the next stage of the selection process.