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Overview

We are seeking a Grade 7 Research Associate in Computer Science for a two-year post within CAPTURE-PH, a multi-centre programme using chest CT and artificial intelligence (AI) to improve the diagnosis, phenotyping and prognostic assessment of pulmonary hypertension associated with interstitial lung disease (PH-ILD). The post will build on RAIDA, the group’s existing cardiothoracic imaging-AI programme, rather than developing a new platform from scratch.

RAIDA brings together AI methods for automated analysis of cardiac chambers, pulmonary vessels and lung parenchyma, with explainable outputs and expert review. Your primary task will be to refine, retrain and technically harden these existing CT assets so that they work reliably across the CAPTURE-PH datasets, initially ASPIRE and PHINDER and subsequently other approved cohorts.

You will address variation in scanners, acquisition protocols and disease phenotypes; undertake quality control and failure analysis; improve segmentation, feature extraction and prediction pipelines; and establish reproducible validation workflows. You will work closely with radiologists, pulmonary vascular clinicians, clinical scientists and statisticians to link RAIDA-derived imaging biomarkers with right-heart catheterisation, clinical measurements and outcomes. The aim is to deliver robust, generalisable research tools and validated imaging outputs that can support CAPTURE-PH analyses and future clinical translation.

Main duties and responsibilities

Refine, adapt and maintain existing RAIDA CT imaging-AI assets for CAPTURE-PH, with initial focus on robust operation across the ASPIRE and PHINDER cohorts.

Audit existing RAIDA pipelines for lung parenchymal, cardiac chamber, large-vessel and pulmonary vascular analysis; identify technical limitations and prioritise changes required for heterogeneous CAPTURE-PH imaging.

Develop and optimise supervised deep-learning methods for segmentation, feature extraction, classification and prediction, including retraining or fine-tuning existing models using expert-reviewed contours and labels where required.

Implement methods to improve generalisability across scanners, vendors, reconstruction methods and acquisition protocols, including appropriate domain-adaptation, semi-supervised or related approaches where these add value.

Design and perform rigorous training, testing and hold-out/external validation, including repeatability, calibration, subgroup performance, bias assessment, quantitative segmentation metrics and clinically relevant diagnostic/prognostic performance measures.

Undertake systematic image review, quality control and failure-mode analysis; work with clinical experts to understand errors, curate difficult cases and feed corrections back into model development.

Create reproducible, version-controlled research software and inference workflows that can process DICOM-derived imaging at scale, generate structured quantitative outputs and operate within approved secure research computing environments.

• Link RAIDA-derived CT biomarkers with right-heart catheterisation, lung function, walk testing, NT-proBNP, MRI and outcome data to support CAPTURE-PH analyses of PH diagnosis, severity, prognosis and treatment-responsive phenotypes.

Support human-in-the-loop review and explainability of model outputs, including integration with approved image-review workflows such as MIM where appropriate, and contribute to documentation needed for reproducibility and future translation.

Contribute to project meetings, milestone reporting, manuscripts, conference presentations and collaborative work with CAPTURE-PH and RAIDA investigators, while following research governance, data-security and quality-assurance requirements.

• Carry out other duties, commensurate with the grade and remit of the post

Person Specification

The selection process will take place following the closing date. This will consist of an interview and a short technical/research presentation or practical discussion relevant to medical-imaging AI. We will let candidates know if they have progressed to the selection stage following the closing date. If you need any support, equipment or adjustments to enable you to participate in any element of the recruitment process you can contact ClinMed-Staffing@sheffield.ac.uk.

Further Information

Next steps in the recruitment process

The selection process will take place following the closing date. This will consist of an interview and a short technical/research presentation or practical discussion relevant to medical-imaging AI. We will let candidates know if they have progressed to the selection stage following the closing date. If you need any support, equipment or adjustments to enable you to participate in any element of the recruitment process you can contact ClinMed-Staffing@sheffield.ac.uk.

Our vision and strategic plan

We are the University of Sheffield. This is our vision: sheffield.ac.uk/vision (opens in new window).

What we offer

• A minimum of 41 days annual leave including bank holiday and closure days (pro rata) with the ability to purchase more.
• Flexible working opportunities, including hybrid working for some roles.
• Generous pension scheme.
• A wide range of discounts and rewards on shopping, eating out and travel.
• A variety of staff networks, providing opportunities for social interaction, peer support and personal development (for example, Race Equality, LGBT+, Women’s and Parent’s networks).
• Recognition Awards to reward staff who go above and beyond in their role.
• A commitment to your development, with access to learning and mentoring schemes.
• A range of generous family-friendly policies
  • paid time off for parenting and caring emergencies
  • and more

Closing Date : 05/10/2026 

We are a research university with a global reputation for excellence. Our ideas and expertise change the world for the better, making a real difference to society. We know that when people come together with different views, approaches and insights it can lead to richer, more creative and innovative teaching and research and the highest levels of student experience. Our University Vision (www.sheffield.ac.uk/vision) outlines our commitment to building a diverse community of staff and students that recognises and values the abilities, backgrounds, beliefs and ways of living for everyone.